Safety & Toxicity Profiling
Safety & Toxicity profiling of compounds is buried within the unstructured text of published medical or scientific literature, companies’ internal documents. Molecular Connections’ proprietary text mining engine helps you identify, retrieve, and normalize metadata from a variety of sources, including organ pathology findings.
Safe and effective therapy is of primal importance in the present day scenario and pharmaceutical companies spend millions in the research and development of drugs that are both safe for human consumption and as well as cost-effective. So assessment of the safety profile of a lead compound/lead series at an early stage of clinical discovery, is of interest to the pharmaceutical companies.
Molecular Connections’ literature curation services can help you retrieve relevant information in a timely manner from a breadth of literature sources. Our custom curation team can help you extract information on drug names, dosages, pathological findings from a wide variety of sources to address critical questions such as:
Adverse or toxicity effects reported (dose specific) for a compound of interest or its analogues
Metabolites of the drug and also on possible drug-drug interactions
On-target or off-target effects of compounds that alter molecular pathway leading to safety issues
Select Case Studies
Safety data was manually curated from scientific literature for a list of molecular targets and drugs provided by the pharmaceutical company in order to prioritize targets for further research and development.
Understanding pharmacologic actions, protein interactions and toxicity studies using XTractorTM. In this case study we extracted the pharmacological actions, protein interactions and toxicity of various drugs and we also manually curated the side-effects from the drug labels